Growth promotion of the opportunistic human pathogen, Staphylococcus lugdunensis , by heme, hemoglobin, and coculture with Staphylococcus aureus
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منابع مشابه
Growth promotion of the opportunistic human pathogen, Staphylococcus lugdunensis, by heme, hemoglobin, and coculture with Staphylococcus aureus
Staphylococcus lugdunensis is both a commensal of humans and an opportunistic pathogen. Little is currently known about the molecular mechanisms underpinning the virulence of this bacterium. Here, we demonstrate that in contrast to S. aureus, S. lugdunensis makes neither staphyloferrin A (SA) nor staphyloferrin B (SB) in response to iron deprivation, owing to the absence of the SB gene cluster,...
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Staphylococcus aureus is a leading cause of life-threatening infections in the United States. It requires iron to grow, which must be actively procured from its host to successfully mount an infection. Heme-iron within hemoglobin (Hb) is the most abundant source of iron in the human body and is captured by S. aureus using two closely related receptors, IsdH and IsdB. Here we demonstrate that ea...
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ژورنال
عنوان ژورنال: MicrobiologyOpen
سال: 2014
ISSN: 2045-8827,2045-8827
DOI: 10.1002/mbo3.162