Gut microbiome-host interactions in health and disease
نویسندگان
چکیده
منابع مشابه
Gut Microbiome and Host Defense Interactions during Critical Illness
For many years it has been hypothesized that the gut has an important detrimental role in promoting systemic inflammation and infection in the critically ill. During stress and mucosal hypoxia, the mucosa is damaged and host defenses break down causing translocation of bacteria and bacterial toxins which are thought to contribute to the overwhelming inflammation associated with sepsis and multi...
متن کاملHost-Microbiome Interactions in Alcoholic Liver Disease
Alcoholic liver disease is a leading cause of morbidity and liver-related death worldwide. Intestinal bacterial overgrowth and dysbiosis induced by ethanol ingestion play an important role in the pathogenesis of alcoholic liver disease. After exposure to alcohol in the lumen, enteric bacteria alter their metabolism and thereby disturb intestinal homeostasis. Disruption of the mucosal barrier re...
متن کاملMINI-REVIEW Microbiome and Host Interactions Gut-liver axis at the frontier of host-microbial interactions
Brandl K, Kumar V, Eckmann L. Gut-liver axis at the frontier of hostmicrobial interactions. Am J Physiol Gastrointest Liver Physiol 312: G413–G419, 2017. First published February 23, 2017; doi:10.1152/ajpgi.00361.2016.—Liver and intestine are tightly linked through the venous system of the portal circulation. Consequently, the liver is the primary recipient of gut-derived products, most promine...
متن کاملGut Microbiome and Neurochemical-based Interactions between Host, Microbiota and Diet: Implications for Behavior and Disease
The ability of the gut microbiome to influence various aspects of host health beyond more traditionally associated functions such as digestion of food is increasingly being recognized (Flint, 2012; Shreiner et al., 2015; Tuddenham and Sears, 2015). While interest over the past decade has grown dramatically, our understanding of the interface between the microbiome and host is still largely, but...
متن کاملTowards an Integrative Understanding of Diet–Host–Gut Microbiome Interactions
Over the last 20 years, a sizeable body of research has linked the microbiome and host diet to a remarkable diversity of diseases. Yet, unifying principles of microbiome assembly or function, at levels required to rationally manipulate a specific individual's microbiome to their benefit, have not emerged. A key driver of both community composition and activity is the host diet, but diet-microbi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Medicine
سال: 2011
ISSN: 1756-994X
DOI: 10.1186/gm228