Haematopoietic stem cells can induce specific skin graft acceptance across full MHC barriers
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چکیده
منابع مشابه
Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells
Objective(s): Although many researchers have confirmed induction of germ cells from bone marrow mesenchymal stem cells (BMMSCs), there are no reports that confirm spontaneous differentiation of germ cells from BMMSCs. In this study, we have evaluated the effect of adult Sertoli cell condition medium (SCCM) as a mutative factor in the induction of germ cells from BMMSCs. Materials and Methods: ...
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Flt3 ligand (FL) dramatically increases the number of immunostimulatory dendritic cells (DC) and their precursors in bone marrow (BM) and secondary lymphoid tissues. Herein we tested the ability of FL-mobilized donor hemopoietic cells to promote induction of skin graft tolerance across full MHC barriers. C57BL/10 (B10; H2(b), IE(-)) mice were given 10(8) spleen cells (SC) from normal or FL-trea...
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The future development of medicine will greatly depend on research, knowledge and clinical application of stem cells. In recent years, stem cells especially; skin stem cells have been very interesting and amazing targets for study and scientific application in the following fields : 1- Cell-based therapy; 2- Regenerative medicine and tissue engineering; 3- Gene therapy; 4- Therapeutic cloning; ...
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Background: Mesenchymal stem cells (MSCs) are considered as effective therapeutic cells in transplantation due to their immunomodulatory activities. However, precise mechanism of MSCs immunomodulatory activity is not completely understood. Objectives: To study the role of Immunoglobulin-like transcripts-3 (ILT3) immunomodulatory receptor in immune tolerance induced by MSCs in skin transpla...
متن کاملThe Full-Thickness Skin Graft.
In I896, Krause reported the use of the same type of graft in a large series of cases and described in great detail a technique which differs little from that employed to-day. In view of this work, in which full credit was given to the earlier reports of Wolfe and others, it is not unreasonable that this graft should be named, as it frequently is, the Wolfe-Krause graft. " Full-thickness," " De...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 1998
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1701277