Haemodynamic effects of cigarette smoking during chronic selective and non-selective beta-adrenoceptor blockade in patients with hypertension.

Selective and Nonselective Beta-adrenoceptor Blockade in Hypertension: Responses

The hypertensive response to the infusion of epinephrine is exaggerated in subjects treated with noncardioselective ,B-adrenergic antagonists, but not in subjects given cardioselective agents. In this study, we sought to determine whether the same holds true when hypertensive patients treated with these drugs are subjected to acute physiologic stress. According to a randomized crossover protoco...

Influence of selective and non-selective beta-adrenoreceptor blockade on the haemodynamic effect of adrenaline during combined antihypertensive drug therapy.

1. Haemodynamic effects of adrenaline were studied in 27 hypertensive patients, succesively during treatment with propranol and metoprolol. In 12 patients beta-adrenoreceptor blockade was combined with diuretics and in 15 patients the blockade was combined with vasodilators. 2. During propranolol adrenaline caused a marked pressor effect: there was a considerable rise in systolic as well as in ...

Selective and non-selective beta receptor blockade in the reduction of portal pressure in patients with cirrhosis and portal hypertension.

To elucidate the mechanisms by which beta receptor blockade leads to a reduction of portal pressure, 18 patients with cirrhosis and portal hypertension were given comparable doses of propranolol or metoprolol. The fall in portal pressure was more marked with propranolol together with a significant reduction in hepatic blood flow, which was not seen with metoprolol. No correlation between the re...

Haemodynamic effects of selective beta-adrenergic blockade during acute stage of myocardial infarction.

The haemodynamic effect of practolol, a cardioselective beta-adrenergic receptor blocker, has been studied in I8 patients during the acute phase of myocardial infarction. After intravenous administration of IO or 20 mg, a negative chronotropic effect was observed which was associated with a moderate decrease in cardiac output but no change in stroke volume. Left ventricular work, ejection time,...

Selective and nonselective beta-adrenoceptor blockade in hypertension: responses to changes in posture, cold and exercise.