Haplotype Frequency Comparison for Case-Parents Data
نویسندگان
چکیده
منابع مشابه
Identification and Frequency Estimation of Inversion Polymorphisms from Haplotype Data
Structural rearrangements, including copy-number alterations and inversions, are increasingly recognized as an important contributor to human genetic variation. Copy number variants are readily measured via array-based techniques like comparative genomic hybridization, but copy-neutral variants such as inversion polymorphisms remain difficult to identify without whole genome sequencing. We intr...
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Comparison of measures for haplotype similarity
Measuring the association of haplotype similarities with phenotype similarities has been used to develop statistical tests of genetic association. Previously, we applied the general approach of Mantel statistics to correlate genetic and phenotype similarity, where genetic similarity was defined by the number of intervals flanked by markers identical by state for pairs of haplotypes. Here we inv...
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Cousin marriage appeared to have a significant role in the birth of disabled children. This is a comparative study on the frequency of cousin and non-cousin marriage among the parents of disabled children and parents of normal children in Kermanshah. In this Ex Post Facto research, employing simple random sampling, 250 parents of disabled children were selected, and the same sample size for par...
متن کاملApplication of sequential haplotype scan methods to case-control data
Haplotype association analysis based on arbitrarily chosen markers might lower statistical power because of the larger number of degrees of freedom caused by irrelevant makers.On the other hand, an exhaustive search for all possible combinations of markers for haplotype analysis is computationally expensive for genome-wide association analysis.To improve power, we applied our recently developed...
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ژورنال
عنوان ژورنال: Open Journal of Statistics
سال: 2018
ISSN: 2161-718X,2161-7198
DOI: 10.4236/ojs.2018.84047