Haplotype Reconstruction Error as a Classical Misclassification Problem: Introducing Sensitivity and Specificity as Error Measures
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چکیده
منابع مشابه
Haplotype Reconstruction Error as a Classical Misclassification Problem: Introducing Sensitivity and Specificity as Error Measures
BACKGROUND Statistically reconstructing haplotypes from single nucleotide polymorphism (SNP) genotypes, can lead to falsely classified haplotypes. This can be an issue when interpreting haplotype association results or when selecting subjects with certain haplotypes for subsequent functional studies. It was our aim to quantify haplotype reconstruction error and to provide tools for it. METHOD...
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Construction of two haplotypes from a set of Single Nucleotide Polymorphism (SNP) fragments is referred to as haplotype reconstruction problem. One of the most important computational models for this problem is Minimum Error Correction (MEC). Since MEC is an NP-hard problem, here we propose a heuristic algorithm for haplotype reconstruction problem. The algorithm is Particle Swarm Optimization ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2008
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0001853