HDAC and HDACi: pathogenetic and mechanistic insights
نویسندگان
چکیده
منابع مشابه
Structural and mechanistic insights into cGMP signaling
Background The second messenger cGMP plays a central role in regulating bodily functions, e.g. in the cardiovascular and nervous systems. cGMP is formed by guanylyl cyclases (GC), activates target proteins, and is finally hydrolyzed by cyclic nucleotide phosphodiesterases (PDE). PDEs and GCs are widely used as drug targets, spurring interest in mechanistic and structural insights into their reg...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2011
ISSN: 1759-4790,1759-4804
DOI: 10.1038/nrrheum.2011.162