HDL Cholesterol and Risk of Type 2 Diabetes: A Mendelian Randomization Study

HDL Cholesterol and Risk of Type 2 Diabetes: A Mendelian Randomization Study.

Observationally, low levels of HDL cholesterol are consistently associated with increased risk of type 2 diabetes. Therefore, plasma HDL cholesterol increasing has been suggested as a novel therapeutic option to reduce the risk of type 2 diabetes. Whether levels of HDL cholesterol are causally associated with type 2 diabetes is unknown. In a prospective study of the general population (n = 47,6...

Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study.

BACKGROUND Coffee is one of the most widely consumed beverages. We tested the hypothesis that genetically high coffee intake is associated with low risk of obesity, metabolic syndrome and type 2 diabetes, and with related components thereof. METHODS We included 93,179 individuals from two large general population cohorts in a Mendelian randomization study. We tested first whether high coffee ...

Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study

Observational studies have shown that elevated systolic blood pressure (SBP) is associated with future onset of type 2 diabetes, but whether this association is causal is not known. We applied the Mendelian randomization framework to evaluate the causal hypothesis that elevated SBP increases risk for type 2 diabetes. We used 28 genetic variants associated with SBP and evaluated their impact on ...

Bilirubin as a potential causal factor in type 2 diabetes risk : a 1 Mendelian randomization study

Bilirubin as a potential causal factor in type 2 diabetes risk: a Mendelian randomization study.

Circulating bilirubin, a natural antioxidant, is associated with decreased risk of type 2 diabetes (T2D), but the nature of the relationship remains unknown. We performed Mendelian randomization in a prospective cohort of 3,381 participants free of diabetes at baseline (age 28-75 years; women 52.6%). We used rs6742078 located in the uridine diphosphate-glucuronosyltransferase locus as an instru...