HDL dysfunction, function, and heart failure
نویسندگان
چکیده
منابع مشابه
Mitochondrial dysfunction in heart failure.
angina was reached. Angina, unfortunately, is a subjective measure. Irrespective of how “objective” the investigators were in determining the success or failure of antianginal therapy, the use of a subjective end point may have inadvertently introduced bias into the trial. It is difficult to draw proper conclusions from such a trial when large crossover rates are allowed. With respect to the Eu...
متن کاملSarcomeric dysfunction in heart failure.
Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure. This review focuses on the alterations in sarcomeric proteins in diseased myocardium that range from altered isoform expression to post-translational protein changes such as proteolysis and phosphorylation. Recent studies in animal models of heart failure and human failing myocardium converge and indi...
متن کاملEndothelial dysfunction in heart failure.
Endothelial dysfunction crucially contributes to the development of impaired coronary and systemic perfusion as well as reduced exercise capacity in patients with congestive heart failure, with fundamental impact on morbidity and mortality. Reduced bioavailability of nitric oxide (NO) and abundant formation of reactive oxygen species (ROS) within the vascular wall are the key determinants in en...
متن کاملHeart failure, redox alterations, and endothelial dysfunction.
Heart failure is characterized by neurohumoral alterations, such as activation of the sympathetic nervous system, stimulation of the renin-angiotensin system, increased activity of the endothelin system, increased production of norepinephrine, and increased circulating levels of cytokines. Oxidative stress is associated with the formation of reactive oxygen species (ROS). The myocardium has enz...
متن کامل[Diastolic dysfunction and diastolic heart failure].
There are frequent clinical Cases in Cardiological practice when cardiac failure develops together with normal systolic function of left ventricle. In these patients after revealing the diastolic dysfunction the heart diastolic failure is diagnosed, but in frequent cases this diagnosis is based on exclusion method. According to Framingham data the number of patients with clinically manifested d...
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ژورنال
عنوان ژورنال: Aging
سال: 2019
ISSN: 1945-4589
DOI: 10.18632/aging.101775