Hedgehog trafficking, cilia and brain functions
نویسندگان
چکیده
منابع مشابه
Trafficking, development and hedgehog
Embryogenesis is mediated by a relatively small number of developmental signaling pathways, and the morphogens, receptors and transcription factors integral to these cascades are considered the master regulators of development. However, superimposed on this is an additional layer of control by complex intracellular trafficking networks. The importance of trafficking in controlling the processes...
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It has been a decade since it was discovered that primary cilia have an essential role in Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that identified a set of genes that are required for both normal Hh signaling and for the formation of primary cilia. Since then, dozens of mouse mutations have been identified that disrupt cilia in a variety of ways and have...
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ژورنال
عنوان ژورنال: Differentiation
سال: 2012
ISSN: 0301-4681
DOI: 10.1016/j.diff.2011.11.011