Hemato-biochemical alterations and antioxidant status during drug-induced thyroid dysfunction in Wister rats

This study was carried to determine the effect of induced disturbance in thyroid hormones (hyperthyroidism and hypothyroidism animal model). In this study, sixty adult male Wister strain rats (180-200 gm) were divided into four groups represented by two control for both drug-induced hyperthyroidism (15/each). Drug-induced group (received 0.4mg thyroxin/100g feed, with normal tap water daily), 0.2% lithium carbonate (Li2CO3) drinking feed daily). Hematological parameters, some serum biochemical assessment oxidative stress MDA levels hepatic renal tissues assessed. Moreover, semi-quantitative scoring histopathological findings investigated. Results revealed that any alterations either if or hyperthyroidism, significantly affect different clinic-pathological profile various body function beside their indirect on tissue conditions changes increase levels. Referring obtained results, most hematological indices, sodium level appeared lower than hypothyroidism; lipid raised. contrast, higher findings, while kidney functions readings. liver enzymes readings readings, accompanied significant decrease albumin hypo- assured microscopically histopathology.