Hematopoietic Effect of Amaranthus cruentus Extract on Cyclophosphamide Induced Toxicity in Rats

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Effect of Lycopene on Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats

Background: Cylophosphamide is used alone or in combination with other drugs for treatment of neoplastic diseases. Hemorrhagic cystitis is a major potential toxicity and dose limiting side effect of cyclophosphamide. The aim of this study was to evaluate the effects of lycopene compared with some antioxidants for the prevention of cyclophosphamide induced hemorrhagic cystitis in rats. Methods: ...

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Ameliorative Effect of Punica Granatum Ethanolic Extract in Cyclophosphamide Induced Testicular Toxicity in Male Wistar Rats

Aim: To explore the potential role of Punica granatum ethanolic extract (PGEE) in Cyclophosphamide (CP) induced testicular toxicity. Methods: Healthy male Wistar rats were allotted to 4 groups (N=6, each) Group I: Control, Group II: CP 15mg/kg twice a week, Group III: PGEE 100mg/kg, Group IV: CP and PGEE for 28 days. At the end of the treatment period, organ weight, body weight, epididymal sper...

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Chemoprotective effect of Crataegus monogyna aqueous extract against cyclophosphamide-induced reproductive toxicity

Cyclophosphamide (CP) is extensively used as an antineoplastic agent for treatment of various cancers, as well as an immunosuppressive agent. However, despite its wide spectrum of clinical uses, CP is known to cause several adverse effects including reproductive toxicity in humans and experimental animals. Crataegus monogyna is one of the oldest medicinal plant has been shown to be cytoprotecti...

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Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats

BACKGROUND Cyclophosphamide (CP) is a nitrogen mustard alkylating drug used for the treatment of chronic and acute malignant lymphomas, myeloma, leukemia, neuroblastoma, adenocarcinoma, retinoblastoma, breast carcinoma, and immunosuppressive therapy. Despite its vast therapeutic uses, it is known to cause severe cardiac toxicity. Kolaviron (KV), a Garcinia kola seed extract containing a mixture...

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ژورنال

عنوان ژورنال: Pharmacognosy Communications

سال: 2019

ISSN: 2249-0167,2249-0159

DOI: 10.5530/pc.2019.4.29