Hemoglobin Pakse: prevalence and geographical distribution

Tertiary structural analysis of the elongated part of an abnormal hemoglobin, hemoglobin Pakse

Hemoglobin variants in which a frameshift results in chain elongation are unusual. Hemoglobin Pakse (Hb Pakse) is an unstable hemoglobin with abnormal elongation, first described in Indochina. An alpha2-globin gene termination codon mutation, TAA -->TAT or Term -->Tyr, has been described in the pathogenesis of Hb Pakse. This abnormality causes a frameshift that elongates the alpha chain amino a...

Geographical distribution of TTR met30 carriers in northern Sweden: discrepancy between carrier frequency and prevalence rate.

The first Swedish case of familial amyloidotic polyneuropathy (FAP) was published in 1965. The same transthyretin (TTR met30) mutation as that seen in Japanese, Portuguese, and other populations was also found in Swedish FAP patients. More than 350 patients with clinical manifestations of FAP have been diagnosed in northern Sweden, most of them originating from the areas around Skellefteå and P...

Febrile Seizures: Etiology, Prevalence, and Geographical Variation

OBJECTIVE Febrile seizures (FSs) are the most common neurological disorder observed in the pediatric age group. The present study provides information about epidemiological and clinical characteristics as well as risk factors associated with FS among Iranian children. MATERIALS & METHODS On the computerized literature valid databases, the FS prevalence and 95% confidence intervals were calcul...

The geographical distribution of cancer.

STUDY of the geographical distribution of cancer has long been recognized to be one way of obtaining clues to its causation, and a great deal of work has been carried out to determine the incidence of different types of cancer in different parts of the world. Detailed incidence rates have been obtained for more than fifty populations, either by national or regional cancer registries or by speci...

Patterns of Geographical Distribution: Animals