Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade
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چکیده
منابع مشابه
Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade
Over the last decade, the role of renin-angiotensin system (RAS) on the development of obesity and its comorbidities has been extensively addressed. Both circulating and local RAS components are up-regulated in obesity and involved in non-alcoholic fatty liver disease onset. Pharmacological manipulations of RAS are viable strategies to tackle metabolic impairments caused by the excessive body f...
متن کاملAT1 Receptor Blockade Attenuates Insulin Resistance and Myocardial Remodeling in Rats with Diet-Induced Obesity
BACKGROUND Although obesity has been associated with metabolic and cardiac disturbances, the carrier mechanisms for these responses are poorly understood. This study analyzed whether angiotensin II blockade attenuates metabolic and cardiovascular disorders in rats with diet-induced obesity. MATERIAL AND METHODS Wistar-Kyoto (n = 40) rats were subjected to control (C; 3.2 kcal/g) and hypercalo...
متن کاملBlockade of hepatic nitric oxide synthase causes insulin resistance.
The hypothesis was tested that insulin sensitivity, previously shown to depend on a functional hepatic parasympathetic reflex, was mediated by hepatic production of nitric oxide (NO). Insulin sensitivity was measured using the rapid insulin sensitivity test. N-nitro-l-arginine methyl ester (l-NAME, 2.5 and 5.0 mg/kg iv) and N-monomethyl-l-arginine (l-NMMA, 0.73 mg/kg), nitric oxide synthase (NO...
متن کاملAT1 and AT2 receptor blockade and epinephrine release during insulin-induced hypoglycemia.
Angiotensin II facilitates epinephrine release during insulin-induced hypoglycemia, and this effect appears to be independent of type 1 angiotensin II (AT1) receptors in man. In the present study, we hypothesized that the action of angiotensin II on adrenomedullary epinephrine release is mediated by an AT2 receptor-dependent mechanism. In conscious chronically instrumented rats, we measured pla...
متن کاملEffect of AT1 receptor blockade on hepatic redox status in SHR: possible relevance for endothelial function?
The study investigated whether the amelioration of endothelial dysfunction by candesartan (2 mg.kg-1.day-1; 10 wk) in spontaneously hypertensive rats (SHR) was associated with modification of hepatic redox system. Systolic arterial pressure (SAP) was higher (P < 0.05) in SHR than in Wistar-Kyoto rats (WKY) and was reduced (P < 0.05) by candesartan in both strains. Acetylcholine (ACh) relaxation...
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ژورنال
عنوان ژورنال: World Journal of Hepatology
سال: 2017
ISSN: 1948-5182
DOI: 10.4254/wjh.v9.i2.74