Hepatic transcriptome perturbations in dairy cows fed different forage resources
نویسندگان
چکیده
Abstract Background Forage plays critical roles in milk performance of dairy. However, domestic high-quality forage such as alfalfa hay is far from being sufficient China. Thus, more than 1 million tons were imported China annually recent years. At the same time, 10 corn stover are generated taking full advantage to meet demand and reduce dependence on has been a strategic policy for Chinese dairy industry. Changes liver metabolism under different resources not well known. objective present study was investigate effect using RNAseq bioinformatics analyses. Results The results this showed that cows fed diet with (CS) main had lower yield, DMI, protein content fat lactose yield mixed (MF) ( P < 0.01). KEGG analysis differently expressed genes (DEG) (81 up-regulated 423 down-DEG, Padj ?0.05) pathways associated glycan biosynthesis amino acid inhibited by CS diet. In addition, DAVID ClueGO indicated biological processes related cell-cell adhesion, multicellular organism growth, also downregulated feeding CS. Co-expression network FAM210A , SLC26A6 FBXW5 EIF6 ZSCAN10 FPGS ARMCX2 played network. Bioinformatics within co-expression enriched “pyruvate metabolic process”, “complement activation, classical pathway”, “retrograde transport, endosome Golgi”. Conclusions low-quality inhibits important functions at least part due reduction DMI. provide an insight into response different-quality resources. As such, data can help develop favorable strategies improve utilization
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2021
ISSN: ['1471-2164']
DOI: https://doi.org/10.1186/s12864-020-07332-0