Hepatocellular Carcinomas: Towards a pathomolecular approach

Molecular analysis of primary liver malignancies has provided a refinement the pathological diagnosis this entity and identification an increasing number tumor subtypes hepatocellular proliferation, either malignant (hepatocellular carcinomas) or benign adenomas). Besides diagnosis, combined pathomolecular approach can also provide further insights into patient prognosis, help select patients who benefit from targeted therapies. Hepatocellular carcinomas define heterogeneous group proliferation at various levels: macroscopic, histological molecular. While most occur in with chronic diseases advanced fibrosis background liver, some arise transformation pre-existing adenoma. TERT promoter mutations are frequent genomic alterations observed process malignancy, they early carcinogenesis. Overall, more active biopsy strategy should be considered key step management HCC.