Hidden Markov modelling of spike propagation from interictal MEG data
نویسندگان
چکیده
منابع مشابه
Hidden Markov modelling of spike propagation from interictal MEG data.
For patients with partial epilepsy, automatic spike detection techniques applied to interictal MEG data often discover several potentially epileptogenic brain regions. An important determination in treatment planning is which of these detected regions are most likely to be the primary sources of epileptogenic activity. Analysis of the patterns of propagation activity between the detected region...
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Synchronous activation of neural networks is an important physiological mechanism, and dysregulation of synchrony forms the basis of epilepsy. We analyzed the propagation of synchronous activity through chronically epileptic neural networks. Electrocorticographic recordings from epileptic patients demonstrate remarkable variance in the pathways of propagation between sequential interictal spike...
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The ability to detect and sort overlapping spike waveforms in extracellular recordings is key to studies of neural coding at high spatial and temporal resolution. Most spike-sorting algorithms are based on initial spike detection (e.g. by a voltage threshold) and subsequent waveform classification. Much effort has been devoted to the clustering step, despite the fact that conservative spike det...
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Objective: MEG dipole localization of epileptic spikes is useful in epilepsy surgery for mapping the extent of abnormal cortex and to focus intracranial electrodes. Visually analyzing large amounts of data produces fatigue and error. Most automated techniques are based on matching of interictal spike templates or predictive filtering of the data and do not explicitly include source localization...
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Interictal MEG dipoles associated with temporal lobe epilepsy (TLE) can be classified according to localization and orientation into anterior temporal horizontal (ATH), anterior temporal vertical and posterior temporal vertical (PTV) dipoles [1, 2, 3]. The MEG dipole pattern may be related to the seizure onset zone [2, 3] or symptomatology [4]. These dipoles are considered to originate from the...
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ژورنال
عنوان ژورنال: Physics in Medicine and Biology
سال: 2005
ISSN: 0031-9155,1361-6560
DOI: 10.1088/0031-9155/50/14/017