High CD33 expression levels in acute myeloid leukemia cells carrying the nucleophosmin (NPM1) mutation
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چکیده
منابع مشابه
High CD33 expression levels in acute myeloid leukemia cells carrying the nucleophosmin (NPM1) mutation.
The CD33 antigen is expressed on the blast cells of most cases of acute myeloid leukemia and represents a suitable tumor-associated target antigen for antibody-based therapies. The aim of this study was to investigate the relationship between the CD33 levels quantified by mean fluorescence intensity and antibody binding capacity, and the presence/absence of NPM1 and FLT3 gene mutations in 99 ne...
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A myeloid leukemia (AML) is a heterogeneous group of clonal hematopoietic stem cell disorders. Numerous recurrent structural and numeric cytogenetic aberrations have been identified, and many of them are not only diagnostic markers for specific AML subtypes, but also constitute independent prognostic factors for attainment of complete remission (CR), relapse risk, and overall survival (OS). Mor...
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Mutations in the nucleophosmin (NPM1) exon 12 resulting in delocalization of NPM1 into the cytoplasm occur in 50% to 60% of acute myeloid leukemia cases with a normal karyotype (AML-NK). As recent studies suggest such patients have a favorable prognosis and there are discordant reports of the immunohistochemical detection of cytoplasmic NPM1 (NPMc+) for predicting NPM1 gene mutations, we correl...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2011
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2011.043786