High-resolution, high-throughput HLA genotyping by next-generation sequencing
نویسندگان
چکیده
منابع مشابه
High-resolution, high-throughput HLA genotyping by next-generation sequencing.
The human leukocyte antigen (HLA) class I and class II loci are the most polymorphic genes in the human genome. Hematopoietic stem cell transplantation requires allele-level HLA typing at multiple loci to select the best matched unrelated donors for recipient patients. In current methods for HLA typing, both alleles of a heterozygote are amplified and typed or sequenced simultaneously, often ma...
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ژورنال
عنوان ژورنال: Tissue Antigens
سال: 2009
ISSN: 0001-2815,1399-0039
DOI: 10.1111/j.1399-0039.2009.01345.x