Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration
نویسندگان
چکیده
منابع مشابه
Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration
BACKGROUND A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest. Previously, we have shown that activation of lysophosphatidic acid receptors (LPARs) via gintonin application potentiates synaptic transmission by the blockade of K(+)...
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Lysophosphatidic acid (LPA) is one of the well-characterized, ubiquitous phospholipid molecules. LPA exerts its effect by activating G protein-coupled receptors known as LPA receptors (LPARs). So far, LPAR signaling has been critically implicated during early development stages, including the regulation of synapse formation and the morphology of cortical and hippocampal neurons. In adult brains...
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ژورنال
عنوان ژورنال: Journal of Ginseng Research
سال: 2016
ISSN: 1226-8453
DOI: 10.1016/j.jgr.2015.05.001