Histological pattern of focal segmental glomerulosclerosis and its clinical correlation

Background: Focal segmental glomerulosclerosis (FSGS) is a pattern of injury and it has five histological subtypes with varying prognosis therapeutic response. Our aim was to study the primary FSGS in our population along their clinicopathological characteristics.Methods: This 2-year retrospective, single centre cohort, observational study. All adult patients were identified.Results: There 51 FSGS. The mean age 37.2±15.3 years overall male dominance. clinical presentations nephrotic syndrome (88.2%), proteinuria hematuria (11.7%), hypertension (47.05%) renal insufficiency (60%). FSGS-NOS seen 26 patients, tip variant 11, perihilar 6, cellular 6 collapsing 2 patients. significantly less than others (20.5±9.1 vs years). Massive higher rest variants had least degree interstitial fibrosis tubular atrophy.Conclusions: which shows variations. Although most commonly affects males, show female preponderance. mostly features chronicity variant. Larger studies are required for differences treatment protocols different variants.