Histomorphological and Immunohistochemical Study of Extra Nodal Lymphoma

Background: NHL are heterogeneous group of hematolymphoid malignancy occurring in nodal and extra sites. Extra lymphoma (ENL) is distinct from lymphomas due to varied anatomical location, morphological diversity.
 Methods: A retrospective observational study was conducted the department pathology January 2011 till December 2019. Clinical details other investigations were recorded. Gross features noted. Slides reviewed microscopically blocks subjected IHC for further typing cases selected as per Dawson et al criteria.
 Result: During period, ENL constituted 25 (29.4%) 85 all NHL. Age range 05 63 years with a mean age 42.5 years. Male female ratio 2.2 :1.Head neck most common site ENHL constituting 19 cases(76%), next commonest location GIT 3 (12%). We had one each case testis, breast spine (4% each). On IHC, 92% (23 cases) exhibited B cell phenotype remaining 08 % (02 T phenotype.
 Conclusion: Lymphomas sites rare but has propensity occur any anatomic site. Hence differential be considered Histology enables differentiate poorly differentiated carcinoma treatment modalities prognosis varies.