Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation
نویسندگان
چکیده
منابع مشابه
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage
Naive T cells differentiate into various effector T cells, including CD4(+) helper T cell subsets and CD8(+) cytotoxic T cells (CTL). Although cytotoxic CD4(+) T cells (CD4 +: CTL) also develop from naive T cells, the mechanism of development is elusive. We found that a small fraction of CD4(+) T cells that express class I-restricted T cell-associated molecule (CRTAM) upon activation possesses ...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2020
ISSN: 2379-3708
DOI: 10.1172/jci.insight.133393