Histopathological validation of safe margin for nephron-sparing surgery based on individual tumor growth pattern

Abstract Background To evaluate the clinicopathologic value of morphological growth patterns small renal cell carcinoma (sRCC) and determine actual demand for taking a rim healthy parenchyma to avoid positive SM. Methods Data was collected from 560 sRCC patients who underwent laparoscopic surgeries May 2010 October 2017. One hundred forty-nine cases received nephron-sparing surgery (NSS) others radical nephrectomy (RN). All specimens were analyzed separately by two uropathologists, three identified. The presence pseudocapsule (PC), surgical margins (SM), other routine variables recorded. relationship between included measured ? 2 test Fisher’s exact probability test. Survival outcomes evaluated Kaplan-Meier method log-rank Results median age 63.2 years old mean tumor diameter 3.0 cm. Four eighty (85.7%) clear RCC 541 (96.6%) at pT1a stage. Peritumoral PC detected in 512 (92.5%) specimens, ratio invasion infiltration pattern increased obviously than that patterns. Similarly, pT stage significantly correlated with as well. NSS 3 (2.0%) them showed SM after operation. Statistical differences 5-year overall survival (OS) cancer-specific (CSS) existed different patterns, status, stages. Conclusions Morphological might be used potential biomarker help operate risk How distinguish before operation effectiveness novel proposed parameter direct deserves further exploration.