HIV Antigens and T‐Cell Receptor Variable Beta Chain Families
نویسندگان
چکیده
منابع مشابه
Identification and characterization of new murine T cell receptor beta chain variable region (V beta) genes
By screening previously isolated genomic clones spanning the mouse TCR V beta locus with V beta-specific oligonucleotides, we have isolated one new functional V beta gene and six V beta pseudogenes. Because this method of identifying new genes does not depend on expression levels, we conclude that most, if not all, V beta genes in the mouse have been identified. The newly identified pseudogenes...
متن کاملPromiscuous Presentation and Recognition of Nucleosomal Autoepitopes in Lupus: Role of Autoimmune TCell Receptor a Chain
T cells specific for nucleosomal autoepitopes are selectively expanded in lupus mice and these Th cells drive autoimmune B cells to produce pathogenic antinuclear antibodies. We transfected the TCRa and b chain genes of a representative, pathogenic autoantibody-inducing Th clone specific for the nucleosomal core histone peptide H4 71–94 into TCR-negative recipient cells. Although the autoimmune...
متن کاملSequences and diversity of human T cell receptor beta chain variable region genes
The nucleotide sequences of 22 human T cell antigen receptor (TcR) beta chain variable region genes isolated from various T lymphocytes have been analyzed. Of the 19 variable gene segment (V beta)-containing sequences, 17 were unique. The V beta gene segments were grouped into 11 families. Comparisons were made with the data of Concannon et al. to unify the nomenclature. The data is consistent ...
متن کاملProduction of Single-Chain Variable-Fragments against Carbohydrate Antigens
The production of human single-chain variable-fragments (scFvs) against carbohydrate antigens by phage display technology is seemingly a logical strategy towards the development of antibody therapeutics, since carbohydrates are self-antigens. Panning and screening of phages displaying human scFvs using a variety of neoglycolipids presenting structurally-defined carbohydrates resulted in a numbe...
متن کاملDevelopmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes
A minor subset of immature (CD4-,8-) thymocytes that lack expression of the B2A2 antigen was found to express low levels of surface TCR protein as detected by mAbs F23.1 and KJ16 (reacting with protein products of the V beta 8 gene family). Interestingly, F23.1/KJ16 determinants were expressed on a two- to three-fold higher proportion of B2A2- thymocytes than mature lymph node T cells in four i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 1997
ISSN: 0300-9475,1365-3083
DOI: 10.1046/j.1365-3083.1997.d01-368.x