HLA and marrow transplants from unrelated donors
نویسندگان
چکیده
منابع مشابه
National Marrow Donor Program HLA-matching guidelines for unrelated marrow transplants.
Department of Oncology, Georgetown University, Washington, DC; Department of Surgery, University of California, San Francisco, California; IBMTR/ABMTR Statistical Center, Medical College of Wisconsin, Milwaukee, Wisconsin; National Marrow Donor Program, Minneapolis, Minnesota; Fred Hutchinson Cancer Research Center, Seattle, Washington; Blood and Marrow Transplant Program, University of Minneso...
متن کاملAssociation of HLA-C disparity with graft failure after marrow transplantation from unrelated donors.
Disparity for HLA-A or HLA-B antigens increases the risk of marrow graft rejection, but the relevance of HLA-C is unknown because typing methods have not been sufficiently accurate for clinical use. We designed a matched case-control study and employed DNA sequencing methods to evaluate the role of HLA-C disparity in 21 patients who experienced graft failure (cases) following transplantation wi...
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BACKGROUND A report from a high-volume single center indicated a survival benefit of receiving a kidney transplant from an HLA-incompatible live donor as compared with remaining on the waiting list, whether or not a kidney from a deceased donor was received. The generalizability of that finding is unclear. METHODS In a 22-center study, we estimated the survival benefit for 1025 recipients of ...
متن کاملPeripheral-blood stem cells versus bone marrow from unrelated donors.
BACKGROUND Randomized trials have shown that the transplantation of filgrastim-mobilized peripheral-blood stem cells from HLA-identical siblings accelerates engraftment but increases the risks of acute and chronic graft-versus-host disease (GVHD), as compared with the transplantation of bone marrow. Some studies have also shown that peripheral-blood stem cells are associated with a decreased ra...
متن کاملThe clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors.
To improve the clinical outcome of allogeneic hematopoietic stem cell transplantation from an unrelated donor, the identification of human leukocyte antigen (HLA) alleles responsible for immunologic events such as graft-versus-host disease (GVHD), engraftment failure, and graft-versus-leukemia effect is essential. Genomic typing of HLA-A, -B, -C, -DRB1, and -DQB1 was retrospectively performed i...
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ژورنال
عنوان ژورنال: Major Histocompatibility Complex
سال: 1994
ISSN: 2186-9995,2187-4239
DOI: 10.12667/mhc.1.19