Homophilic Adhesion Mechanism of Neurofascin, a Member of the L1 Family of Neural Cell Adhesion Molecules
نویسندگان
چکیده
منابع مشابه
Cryo-electron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1.
The neural cell adhesion molecule L1 participates in homophilic interactions important for axon guidance and neuronal development. The structural details of homophilic adhesion mediated by L1 and other immunoglobulin superfamily members containing an N-terminal horseshoe arrangement of four immunoglobulin-like domains are unknown. Here we used cryo-electron tomography to study liposomes to whic...
متن کاملThe L1 Family of Neural Cell Adhesion Molecules: Old Proteins Performing New Tricks
Michael Hortsch chordate phyla (Figure 2). Subsequently, at some point during early chordate evolution, a further separation into Department of Anatomy and Cell Biology University of Michigan three different L1 subfamilies occurred. As exemplified by the two L1-CAM-type molecules found in zebrafish Ann Arbor, Michigan 48109-0616 (Tongiorgi et al., 1995), additional members of the L1 family migh...
متن کاملPathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities.
Mutations in the gene for neural cell adhesion molecule L1 (L1CAM) result in a debilitating X-linked congenital disorder of brain development. At the neuronal cell surface L1 may interact with a variety of different molecules including itself and two other CAMs of the immunoglobulin superfamily, axonin-1 and F11. However, whether all of these interactions are relevant to normal or abnormal deve...
متن کاملCancer cells cut homophilic cell adhesion molecules and run.
The term contact inhibition (CI) encompasses the cellular changes that result in cessation of cell migration and of proliferation due to signals transduced when one cell comes into physical contact with another cell. Cancer cells, however, do not contact inhibit. A molecular understanding of the loss of CI in cancer cells is important for understanding tumor progression. In this Perspective, we...
متن کاملBrain development in mice lacking L1–L1 homophilic adhesion
A new mouse line has been produced in which the sixth Ig domain of the L1 cell adhesion molecule has been deleted. Despite the rather large deletion, L1 expression is preserved at normal levels. In vitro experiments showed that L1-L1 homophilic binding was lost, along with L1-alpha5beta1 integrin binding. However, L1-neurocan and L1-neuropilin binding were preserved and sema3a responses were in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.180281