Host adaptation mechanisms of Influenza A viruses
نویسندگان
چکیده
منابع مشابه
Charting the Host Adaptation of Influenza Viruses
Four influenza pandemics have struck the human population during the last 100 years causing substantial morbidity and mortality. The pandemics were caused by the introduction of a new virus into the human population from an avian or swine host or through the mixing of virus segments from an animal host with a human virus to create a new reassortant subtype virus. Understanding which changes hav...
متن کاملHost-range barrier of influenza A viruses.
Ample evidence suggests that all influenza viruses in mammals were probably derived from those in wild waterfowl at some time. In addition to those already established in mammals, the viruses have been transmitted to both mammals and to poultry from wild waterfowl and caused outbreaks in recent years. Experimentally, however, the viruses from one species of animals do not grow efficiently in ot...
متن کاملWithin-host variation of avian influenza viruses.
The emergence and spread of H5N1 avian influenza viruses from Asia through to Europe and Africa pose a significant animal disease problem and have raised concerns that the virus may pose a pandemic threat to humans. The epizootological factors that have influenced the wide distribution of the virus are complex, and the variety of viruses currently circulating reflects these factors. Sequence an...
متن کاملAdaptation of pandemic H2N2 influenza A viruses in humans.
The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates a...
متن کاملNucleotide host markers in the influenza A viruses
In the efforts to understand the molecular characteristics responsible for the ability of influenza viruses to cross species, various amino acid host markers in influenza viruses were uncovered. Our previous study identified a collection of novel amino acid host markers in ten proteins of 2009 pandemic H1N1. As an extension of our prior work, the objective of the current study was to employ Ran...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Uirusu
سال: 2008
ISSN: 0042-6857
DOI: 10.2222/jsv.58.69