How Meaningful Are Minor Details in the Generation of Nanomodified Electrochemical Enzyme Biosensors? Exploring the Scenario with Sinusoidal Approaches

In this work, a screening of Sonogel-Carbon (SNGC) electrodes modified with nanomaterials (carbon nanotubes and gold nanoparticles) the study their effect on electrochemical performance sinusoidal voltage (SV) current (SC)-based biosensors are reported. Surface modification was achieved by drop-casting electrodeposition methodologies. Within strategies used, SV SC, recently exploited procedures, were used to electrodeposit simultaneously poly 3,4-ethylenedioxythiophene (PEDOT)-tyrosinase layer corresponding nanostructured material. Dopamine selected as benchmark analyte evaluate analytical different (bio)sensors obtained in terms relevant figures merit, such sensitivity, limits detection quantitation, accuracy, among others. A discussion about pros cons between type methods employed is also presented. Briefly, SC based sensors offered excellent quality parameters lower dispersion results. They for more specific studies, including interferences assays determination DA real samples, obtaining good recoveries (101–110.6%). The biosensor nanoparticles (AuNPs) (drop-casting method) SC-electrodeposited showed best merit: R2 = 0.999; sensitivity −4.92 × 10−9 A·µM−1; RSDsensitivity 1.60%; LOD 5.56 µM; RSDLOD 6.10%; LOQ 18.53 µM.