Human B-cell ontogeny in humanized NOD/SCID γcnull mice generates a diverse yet auto/poly- and HIV-1-reactive antibody repertoire
نویسندگان
چکیده
منابع مشابه
I-1: Spermatogonial Ontogeny in Mice
Background:Spermatogenesis is maintained by a pool of the spermatogonia. The group formed by As, Apr and Aal is known as undifferentiated type a spermatogonia (Aund). The Aal spermatogonia will differentiate, with no mitotic division, to the differentiating type A1 spermatogonia. The type A1 spermatogonia undergo 6 successive mitotic divisions to yield A2, A3, A4, intermediate-type (In), and ty...
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Marsupials are a lineage of mammals noted for giving birth to highly altricial young, which complete much of their "fetal" development externally attached to a teat. Postnatal B cell ontogeny and diversity was investigated in a model marsupial species, the gray short-tailed opossum, Monodelphis domestica. The results support the initiation of B cell development late in gestation and progressing...
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Stable engraftment of human lymphoid tissue in NOD/scid-IL-2Rgammacnull mice after CD34+ hematopoietic stem cell reconstitution permits the evaluation of ongoing HIV-1 infection for weeks to months. We demonstrate that HIV-1-infected rodents develop virus-specific cellular immune responses. CD8+ cell depletion, 2 or 5-7 wk after viral infection, resulted in a significant increase of HIV-1 load,...
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The extent of B cell repertoire diversity among nu/nu BALB/c mice has been assessed and compared with that of normal BALB/c mice. This was accomplished through the characterization of monoclonal, influenza hemagglutinin-specific antibodies by reactivity pattern analysis. The results indicate that the repertoire of athymic mice is equivalent in diversity to that of normal mice. Moreover, because...
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Reconstitution of the human Ig repertoire after allogeneic and autologous bone marrow transplantation (BMT) was followed by analysis of the expression of the six VH families using in situ hybridization on BM cells at 30, 60, and 90 days postgraft. Our results indicate that during the early post-transplantation period, the expressed repertoire of VH is dramatically affected: VH3, the major expre...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2012
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2012.16