Human dUTP pyrophosphatase: uracil recognition by a β hairpin and active sites formed by three separate subunits
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چکیده
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متن کاملStructures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
dUTP pyrophosphatase (dUTPase) cleaves the alpha-beta phosphodiester of dUTP to form pyrophosphate and dUMP, preventing incorporation of uracil into DNA and providing the substrate for thymine synthesis. Seven crystal structures of feline immunodeficiency virus (FIV) dUTPase in three crystal forms have been determined, including complexes with substrate (dUTP), product (dUMP) or inhibitor (dUDP...
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متن کاملStructural characterisation of a uracil containing hairpin DNA by NMR and molecular dynamics.
Three-dimensional (3D) structure of a hairpin DNA d-CTAGAGGATCCTTTUGGATCCT (22mer; abbreviated as U4-hairpin), which has a uracil nucleotide unit at the fourth position from the 5' end of the tetra-loop has been solved by NMR spectroscopy. The(1)H resonances of this hairpin have been assigned almost completely. NMR restrained molecular dynamics and energy minimisation procedures have been used ...
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ژورنال
عنوان ژورنال: Structure
سال: 1996
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(96)00114-1