Human endogenous retrovirus-R (ERV 3) env-like antigens expressed in baboon testes and epididymides

Human endogenous retrovirus-like sequences.

One of the most salient features of the replication strategy used by retroviruses is the transcription of the retroviral (RNA) genome into DNA followed by integration of this DNA product into the host cell genome. The integrated viral DNA copy, termed "provirus", can then serve as a template for the synthesis of further infectious virus particles. Stably integrated proviruses have been found to...

Placental endogenous retrovirus (ERV): structural, functional, and evolutionary significance.

That endogenous retrovirus (ERV) is present within the placenta of humans and other mammals has been known for the past 25 years, but the significance of this observation is still not fully understood. Much molecular biological data have emerged in recent years to support the earlier electron microscopic data on the presence of placental ERV. The evidence for ERV in animal and human placental t...

Endogenous Retrovirus Erv-3 Is Not Implicated in Rheumatoid Arthritis But

ERV-L elements: a family of endogenous retrovirus-like elements active throughout the evolution of mammals.

We have previously identified in the human genome a family of 200 endogenous retrovirus-like elements, the HERV-L elements, disclosing similarities with the foamy retroviruses and which might be the evolutionary intermediate between classical intracellular retrotransposons and infectious retroviruses. Southern blot analysis of a large series of mammalian genomic DNAs shows that HERV-L-related e...

Estimation of human endogenous retrovirus activities from expressed sequence databases

Human endogenous retroviruses (HERVs) are remnants of ancient retrovirus infections and now reside within the human DNA. Recently HERV expression has been detected in both normal tissues and diseased patients. However, the activities (expression levels) of individual HERV sequences are mostly unknown. In this work we introduce a generative mixture model, based on Hidden Markov Models, for estim...