Human obstructive (postvasectomy) and nonobstructive azoospermia – Insights from scRNA-Seq and transcriptome analysis
نویسندگان
چکیده
منابع مشابه
Surgical management of nonobstructive azoospermia
Nonobstructive azoospermia (NOA) is characterized by the complete absence of sperm in the ejaculate due to testicular failure. The evaluation and management of patients with NOA offer a challenge to the reproductive urologist. In the era of in vitro fertilization with intracytoplasmic sperm injection, surgical sperm extraction techniques can afford men with NOA biologic paternity. To provide a ...
متن کاملObstructive and Non-Obstructive Azoospermia
Azoospermia is defined as the complete absence of spermatozoa upon examination of the semen [including capillary tube centrifugation (CTC), strictly confirmed by the absence of spermatozoa issued in urine after ejaculation]. The presence of rare spermatozoa (<500.000/ml) in seminal fluid after centrifugation is called "cryptozoospermia". The complete absence of spermatozoa should be confirmed w...
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In this abstract, we propose several computational approaches for clustering scRNA-Seq data based on the Term Frequency Inverse Document Frequency (TF-IDF) transformation that has been successfully used in the field of text analysis. Empirical evaluation on simulated cell mixtures with different levels of complexity suggests that the TF-IDF methods consistently outperform existing scRNA-Seq clu...
متن کاملComputational approaches for interpreting scRNA‐seq data
The recent developments in high-throughput single-cell RNA sequencing technology (scRNA-seq) have enabled the generation of vast amounts of transcriptomic data at cellular resolution. With these advances come new modes of data analysis, building on high-dimensional data mining techniques. Here, we consider biological questions for which scRNA-seq data is used, both at a cell and gene level, and...
متن کاملVaricocele repair in patients with nonobstructive azoospermia: a meta-analysis.
PURPOSE Multiple small case series have reported sperm in the ejaculate and spontaneous pregnancies in patients with nonobstructive azoospermia after varicocele repair. We hypothesized that men with favorable testicular histopathology on testis biopsy such as maturation arrest or hypospermatogenesis would have a higher probability of success than those with more ablative pathology, eg Sertoli-c...
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ژورنال
عنوان ژورنال: Genes & Diseases
سال: 2020
ISSN: 2352-3042
DOI: 10.1016/j.gendis.2020.09.004