Human Platelet Lysate Promotes Proliferation but Fails to Maintain Chondrogenic Markers of Chondrocytes
نویسندگان
چکیده
منابع مشابه
Comparison between Chondrogenic Markers of Differentiated Chondrocytes from Adipose Derived Stem Cells and Articular Chondrocytes In Vitro
Objective(s): Osteoarthritis is one of the most common diseases in middle-aged population in the world. Cartilage tissue engineering (TE) has been presented as an effort to introduce the best combination of cells, biomaterial scaffolds and stimulating growth factors to produce a cartilage tissue similar to the natural articular cartilage. In this study, the chondrogenic potential of adipose d...
متن کاملInfluence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells.
BACKGROUND/AIMS Autologous chondrocyte (CC) transplantation has the disadvantages of requiring two surgical interventions and in vitro expansion of cells, implying the risk of cellular dedifferentiation. Our clinical aim is to develop a one-step procedure for autologous CC transplantation, i.e. harvesting, isolation and reimplantation of CC performed in one single surgical procedure. Platelet-r...
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Slow growth and rapid loss of chondrogenic phenotypes are the major problems affecting chronic cartilage lesions. The role of microRNA-195 (miR-195) and its detailed working mechanism in the fore-mentioned process remains unknown. Fibroblastic growth factor 18 (FGF-18) plays a key role in cartilage homeostasis; whether miR-195 could regulate FGF-18 and its downstream signal pathway in chondrocy...
متن کاملDonor Age of Human Platelet Lysate Affects Proliferation and Differentiation of Mesenchymal Stem Cells
The regenerative potential declines upon aging. This might be due to cell-intrinsic changes in stem and progenitor cells or to influences by the microenvironment. Mesenchymal stem cells (MSC) raise high hopes in regenerative medicine. They are usually culture expanded in media with fetal calf serum (FCS) or other serum supplements such as human platelet lysate (HPL). In this study, we have anal...
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Galway, Ireland Platelet Lysate Promotes Wound Closure of Human Kertinocytes Under Physiologic And Inflammatory Conditions Rania El Backly, Laura Tonachini , Fiorella Descalzi, Ranieri Cancedda, Maddalena Mastrogiacomo Corresponding author: Maddalena Mastrogiacomo 1 Laboratorio di Medicina Rigenerativa, Dipartimento di Oncologia, Biologia e Genetica, Università degli Studi di Genova, Genova, It...
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ژورنال
عنوان ژورنال: Sains Malaysiana
سال: 2019
ISSN: 0126-6039
DOI: 10.17576/jsm-2019-4810-12