Human telomerase reverse transcriptase expression in ovarian tumors
نویسندگان
چکیده
منابع مشابه
Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms.
Ten percent of fine-needle aspirations (FNAs) of the thyroid are deemed "indeterminate" or "suspicious" for malignancy by the cytopathologist, but most of these lesions are benign. Therefore, additional markers of malignancy may prove to be a useful adjunct. The catalytic component of telomerase, human telomerase reverse transcriptase (hTERT), has been found to be reactivated in immortalized ce...
متن کاملHuman telomerase reverse transcriptase gene expression and the surgical management of suspicious thyroid tumors.
PURPOSE Patients with a preoperative cytologic diagnosis of a suspicious thyroid nodule present a therapeutic dilemma because surgery differs for benign and malignant lesions. To address this issue, several molecular markers, including human telomerase reverse transcriptase (TERT), have been tested as markers of thyroid cancer. Because most studies select cases falling into well-defined categor...
متن کاملtargeting human telomerase reverse transcriptase by a simple sirna expression cassette in hepg2 cells
background human telomerase reverse transcriptase (htert) has become an ideal target for development of anticancer therapy. small interfering rnas (sirnas) are very powerful reagents for gene silencing and show promise for cancer gene therapy. however, only a small number of sirnas have been demonstrated to be effective. for gene therapy targeting htert, it is essential to develop a robust syst...
متن کاملCorrelation with Grade, Histology, and Proliferative Activity Transcriptase mRNA Expression in Soft Tissue Tumors : Telomerase Activity and Human Telomerase Reverse
Telomerase activity (TA) is detected in most human cancers but, with few exceptions, not in normal somatic cells. Little is known about TA in soft tissue tumors. We have examined a series of benign and malignant soft tissue tumors for TA using the telomerase repeat amplification protocol assay. Analysis of the expression of the human telomerase reverse transcriptase was also carried out using R...
متن کاملTelomerase activity and human telomerase reverse transcriptase mRNA expression in soft tissue tumors: correlation with grade, histology, and proliferative activity.
Telomerase activity (TA) is detected in most human cancers but, with few exceptions, not in normal somatic cells. Little is known about TA in soft tissue tumors. We have examined a series of benign and malignant soft tissue tumors for TA using the telomerase repeat amplification protocol assay. Analysis of the expression of the human telomerase reverse transcriptase was also carried out using R...
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ژورنال
عنوان ژورنال: Indian Journal of Pathology and Microbiology
سال: 2012
ISSN: 0377-4929
DOI: 10.4103/0377-4929.97865