Humoral immune response within the lung in HIV-1 infection

An HIV-1 Mini Vaccine Induced Long-lived Cellular and Humoral Immune Responses

Memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. The main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. Mice were immunized with human immunodeficiency virus-1 P24-Nef fusion peptide and then cellular and humoral immune responses were evaluated. In order to determin...

Can the immune response control HIV infection?

Human immunodeficiency virus (HIV) constitutes an unprecedented challenge to medical science. Once an HIV infection is established, its clinical course, while protracted , is generally inexorable. With the possible exception of a group of recently described "long-term nonpro-gressors," virtually all HIV-infected individuals eventually develop acquired immunodeficiency syndrome (AIDS), the outco...

Humoral Immune Response to Mumps (RS-12 strain) Vaccine of Children 1-7 Years Old

The humoral immune response to HIV-1: Consequences for vaccine design

Some 42 million individuals worldwide are infected by the Human Immunodeficiency Virus (HIV) and no cure or vaccine is available. This thesis addresses approaches to humoral immunity to HIV-1. In primary infection, the cytotoxic T lymphocyte (CTL) response is detected early and is thought to play a role in the viral decline. Neutralising antibodies (NAbs) are detected much later. However, non-n...

A humoral immune response confers protection against Haemophilus ducreyi infection.

Haemophilus ducreyi is the etiologic agent of the sexually transmitted genital ulcer disease chancroid. Neither naturally occurring chancroid nor experimental infection with H. ducreyi results in protective immunity. Likewise, a single inoculation of H. ducreyi does not protect pigs against subsequent infection. Accordingly, we used the swine model of chancroid infection to examine the impact o...