Hydroxychloroquine versus hydroxychloroquine-azithromycin combination therapy on QT interval prolongation of COVID-19 patients: a systematic review and meta-analysis

نویسندگان

چکیده

VĂ˝zkum zaměřenĂ˝ na léčbu onemocněnĂ­ COVID-19 vedl k pouĹžitĂ­ hydroxychlorochinu (HCQ) jako jednĂŠ z moĹžnostĂ­ léčby. Účinnost HCQ lze zvýťit jeho podĂĄvĂĄnĂ­m v kombinaci s azitromycinem (AZM). Hydroxychlorochin vĹĄak mĹŻĹže spouĹĄtět arytmie podobě prodlouĹženĂ­ intervalu QT. PřidĂĄnĂ­ AZM by rovněž mohlo riziko ProtoĹže mechanismus účinku těchto lĂĄtek stĂĄle nenĂ­ přesně znĂĄm, je naprosto nezbytnĂŠ provĂŠst systematickĂ˝ přehled vĂ˝sledkĹŻ dosavadnĂ­ho vĂ˝zkumu. CĂ­lem předloĹženĂŠ studie bylo porovnat incidenci QT u pacientĹŻ onemocněnĂ­m léčenĂ˝ch a kombinacĂ­ HCQ-AZM. UspořádĂĄnĂ­m se jednalo o komparativnĂ­ studii dvou samostatnĂ˝ch skupin pacientĹŻ. Údaje byly shromažďovĂĄny časopisĹŻ publikovanĂ˝ch online obdobĂ­ od ledna do července 2020, nichĹž srovnĂĄvala incidence buď samotnĂ˝m, nebo HCQ-AZM; člĂĄnky nĂĄsledně zařazeny systematickĂŠho přehledu. Bylo nalezeno pět studiĂ­ splňujĂ­cĂ­ch zadanĂĄ kritĂŠria; vĂ˝slednĂ˝ vzorek zahrnoval 477 osob ve Francii USA. zpracovĂĄny formou deskriptivnĂ­ statistickĂŠ analĂ˝zy. StatistickĂĄ analĂ˝za provĂĄděla pomocĂ­ fixnĂ­ho modelu pouĹžitĂ­m poolovanĂ˝ch ĂşdajĹŻ. AnalĂ˝za nenalezla ŞådnĂ˝ statisticky vĂ˝znamnĂ˝ rozdĂ­l vĂ˝skytu mezi skupinami léčenĂ˝mi pouze HCQ, HCQ-AZM (OR 1,294; 95% CI 0,707-2,370). © 2021, ČKS.

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ژورنال

عنوان ژورنال: Cor et vasa

سال: 2021

ISSN: ['0010-8650', '1803-7712']

DOI: https://doi.org/10.33678/cor.2021.025