Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes1✪
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چکیده
منابع مشابه
Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes1〉
A key event in the pathogenesis of allergies is the production of antibodies of the immunoglobulin (Ig)E class. In normal individuals the levels of IgE are tightly regulated, as illustrated by the low serum IgE concentration. In addition, multiple immunizations are usually required to generate detectable IgE responses in normal experimental animals. To define the parameters that regulate IgE pr...
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The transgenic mice were produced by injecting eggs of B6 and C3H/HeJ mice with the human E mu-myc gene. Preferential development of B lymphomas was observed in the B6 transgenic mice, whereas the C3H/HeJ transgenic mice developed mostly T lymphomas. The phenotypic activation of B lineage cells but not of T lineage cells was detected in the prelymphomatous transgenic mice of both strains. The t...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2001
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.194.9.1349