Hypercoagulopathy, acquired coagulation disorders and anticoagulation before, during and after extracorporeal membrane oxygenation in COVID-19: a case series
نویسندگان
چکیده
Background: Thromboembolism and bleeding contribute to Coronavirus disease 2019 (COVID-19)’s morbidity mortality are also frequent complications of venovenous extracorporeal membrane oxygenation (vvECMO). As the interaction underlying pathologies caused by vvECMO in COVID-19 is barely understood, we designed this study better differentiate coagulation disorders patients before, during after vvECMO-support. Methods: Observational case series, six consecutive with acute respiratory distress syndrome supported treated anaesthesiologic ICU a third level University ECMO-centre. We measured routine parameters assessed factors. conducted advanced von Willebrand factor (VWF) multimer analysis, platelet aggregometry immunological screening. Results: identified various phases disorders: Initially, intensely activated highly increased VWF VIII activity COVID-19, then severe acquired dysfunction leading spontaneous finally, hypercoagulopathy explantation. Five developed abnormalities enhancing coagulation. Conclusions: Coronavirus-induced coagulopathy cannot be discriminated via ‘routine’ tests. Precise specific analyses followed appropriate treatment may help us develop tailored therapeutic concepts manage described above.
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ژورنال
عنوان ژورنال: Perfusion
سال: 2021
ISSN: ['0267-6591', '1477-111X']
DOI: https://doi.org/10.1177/02676591211001791