Hypericum extract was better than placebo and equivalent to imipramine for moderate depression
نویسندگان
چکیده
منابع مشابه
Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks.
OBJECTIVES To assess the efficacy and safety of hypericum extract (STEI 300, Steiner Arzneimittel, Berlin) compared with imipramine and placebo in patients in primary care with a current episode of moderate depression. DESIGN Randomised, double blind, multicentre, parallel group trial for 8 weeks. SETTING Trained panel of 18 general practitioners from four German states: Bavaria, Berlin, Rh...
متن کاملSt John's wort was not better than placebo for reducing depression scores.
Patients 200 physically healthy outpatients who were >18 years of age (mean age 42.4 y, 64% women); had MD (single episode or recurrent) without psychotic features according to DSM-IV for >4 weeks; and scored >20 on the Hamilton Depression Rating Scale (HDRS). Exclusion criteria included current cognitive, post-traumatic stress, eating, or substance use disorders in the past 6 months; panic dis...
متن کاملEfficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression.
Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials ...
متن کاملComparison of St John's wort and imipramine for treating depression: randomised controlled trial.
OBJECTIVES To compare the efficacy and tolerability of Hypericum perforatum (St John's wort extract) with imipramine in patients with mild to moderate depression. DESIGN Randomised, multicentre, double blind, parallel group trial. SETTING 40 outpatient clinics in Germany. PARTICIPANTS 324 outpatients with mild to moderate depression. INTERVENTION 75 mg imipramine twice daily or 250 mg h...
متن کاملSt John's wort was not better than placebo for reducing symptoms in major depressive disorder.
Patients 340 outpatients who were ≥ 18 years of age (mean age 42 y, 66% women); had a current diagnosis of MDD; and scored ≥ 20 on the Hamilton Depression Rating Scale (HDRS) (mean score 22.8) and ≤ 60 on the Global Assessment of Functioning (mean score 53.6) after a 1 week placebo run in period. Exclusion criteria included a score > 2 on the HDRS suicide item, serious physical or psychiatric d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2000
ISSN: 1356-5524
DOI: 10.1136/ebm.5.4.116