Hyperlactatemia in patients without tissue hypoperfusion
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چکیده
منابع مشابه
Massive amounts of tissue factor induce fibrinogenolysis without tissue hypoperfusion in rats.
Trauma-induced tissue factor (TF) release into the systemic circulation is considered to play an important role in the development of disseminated intravascular coagulation (DIC) immediately after severe trauma. However, the relationship between TF and hyperfibrinolysis, especially fibrinogenolysis, has been unclear. A total of 18 rats were divided into three groups: (a) the control group was i...
متن کاملSepsis-induced tissue hypoperfusion.
The understanding of sepsis is continuously evolving. An overview of sepsis-induced tissue hypoperfusion has been provided herein. It is of critical importance that the clinician understands the pathophysiology of this emergent condition and is able to synthesize the available data in a rapid fashion so that tissue hypoperfusion is readily detected. Once detected, aggressive and endpoint-direct...
متن کاملSepsis-induced tissue hypoperfusion
Sepsis is associated with cardiovascular changes that may lead to development of tissue hypoperfusion. Early recognition of sepsis and tissue hypoperfusion is critical to implement appropriate hemodynamic support and prevent irreversible organ damage. End points for resuscitation need to be defined and invasive hemodynamic monitoring is usually required. Targets for hemodynamic optimization sho...
متن کاملA hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study
BACKGROUND Persistent hyperlactatemia is particularly difficult to interpret in septic shock. Besides hypoperfusion, adrenergic-driven lactate production and impaired lactate clearance are important contributors. However, clinical recognition of different sources of hyperlactatemia is unfortunately not a common practice and patients are treated with the same strategy despite the risk of over-re...
متن کاملHemodynamic optimization of sepsis-induced tissue hypoperfusion
Sepsis is associated with cardiovascular changes that may lead to development of tissue hypoperfusion. Early recognition of sepsis and tissue hypoperfusion is critical to implement appropriate hemodynamic support and prevent irreversible organ damage. End points for resuscitation need to be defined and invasive hemodynamic monitoring is usually required. Targets for hemodynamic optimization sho...
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ژورنال
عنوان ژورنال: Nihon Shuchu Chiryo Igakukai zasshi
سال: 2006
ISSN: 1340-7988,1882-966X
DOI: 10.3918/jsicm.13.73