Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H
نویسندگان
چکیده
منابع مشابه
Inhibition of hepatitis B virus replication by APOBEC3G.
The cytidine deaminase APOBEC3G (A3G) was recently identified as a natural resistance gene that restricts efficient propagation of human immunodeficiency virus and other retroviruses. The enzyme induces massive cytidine to uridine (C3U) deamination of single-stranded retroviral DNA, resulting in DNA degradation or lethal guanine to adenine (G3A) hypermutation (1). Hepadnaviruses, including hepa...
متن کاملUracil DNA Glycosylase Counteracts APOBEC3G-Induced Hypermutation of Hepatitis B Viral Genomes: Excision Repair of Covalently Closed Circular DNA
The covalently closed circular DNA (cccDNA) of the hepatitis B virus (HBV) plays an essential role in chronic hepatitis. The cellular repair system is proposed to convert cytoplasmic nucleocapsid (NC) DNA (partially double-stranded DNA) into cccDNA in the nucleus. Recently, antiviral cytidine deaminases, AID/APOBEC proteins, were shown to generate uracil residues in the NC-DNA through deaminati...
متن کاملNaturally occurring hepatitis B virus genomes bearing the hallmarks of retroviral G-->A hypermutation.
Two hypermutated genomes of hepatitis B virus (HBV) were cloned from sera of chronic virus carriers. Twelve percent and 26% of guanosine residues were replaced by adenosine, with the transitions being erratically distributed along the genome. G-->A substitutions showed a strong dinucleotide preference, decreasing in the order GpA > GpG > > GpC > or = GpT. Such traits are typical of retroviral G...
متن کاملDual effect of APOBEC3G on Hepatitis B virus.
G to A hypermutation of Hepatitis B virus (HBV) and retroviruses appears as a result of deamination activities of host APOBEC proteins and is thought to play a role in innate antiviral immunity. Alpha and gamma interferons (IFN-alpha and -gamma) have been reported to upregulate the transcription of APOBEC3G, which is known to reduce the replication of HBV. We investigated the number of hypermut...
متن کاملDeamination-independent inhibition of hepatitis B virus reverse transcription by APOBEC3G.
The APOBEC3 family of mammalian cytidine deaminases, including APOBEC3G (A3G), has been shown to function as innate antiviral factors against retroviruses and can also suppress the replication of the hepatitis B virus (HBV). The mechanism by which A3G inhibits HBV replication remains to be elucidated. In this study, we show that the inhibitory effect of APOBEC3 proteins on HBV replication was m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2008
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.83507-0