Hyperpolarized NMR Spectroscopy: d ‐DNP, PHIP, and SABRE Techniques
نویسندگان
چکیده
منابع مشابه
Molecular Sensing Using Hyperpolarized Xenon NMR Spectroscopy
Although proton-based magnetic resonance imaging (MRI) provides a powerful modality for clinical imaging with excellent spatial resolution, it is not well suited to imaging void spaces (i.e., the lungs), low-abundance molecular markers of disease, or environments where unique proton spin densities are low. To address this limitation, hyperpolarized (hp) xenon-based NMR spectroscopy and MRI have...
متن کامل2H-DNP-enhanced 2H-13C solid-state NMR correlation spectroscopy.
Perdeuteration of biological macromolecules for magic angle spinning solid-state NMR spectroscopy can yield high-resolution (2)H-(13)C correlation spectra and the method is therefore of great interest for the structural biology community. Here we demonstrate that the combination of sample deuteration and dynamic nuclear polarization yields resolved (2)H-(13)C correlation spectra with a signal e...
متن کاملNon-aqueous solvents for DNP surface enhanced NMR spectroscopy.
A series of non-aqueous solvents combined with the exogenous biradical bTbK are developed for DNP NMR that yield enhancements comparable to the best available water based systems. 1,1,2,2-tetrachloroethane appears to be one of the most promising organic solvents for DNP solid-state NMR. Here this results in a reduction in experimental times by a factor of 1000. These new solvents are demonstrat...
متن کاملIncreased volumetric activity for hyperpolarized DNP solutions
Introduction: Maximizing the activity of the polarization for C labeled compounds is critical for in vivo or in vitro imaging or spectroscopy in hyperpolarized C studies. In most systems using the dynamic nuclear polarization (DNP) method a larger volume of water containing EDTA is used to extract a concentrated smaller volume (typically less than ≤100 μl) of a frozen solution consisting of the...
متن کاملHyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism.
Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarization-parahydrogen and synthesis allow dramatically enhanced nuclear alignment [PHIP-PASADENA]; xenon/helium polarization transfer; Brute Force; (1)H hype...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry – An Asian Journal
سال: 2018
ISSN: 1861-4728,1861-471X
DOI: 10.1002/asia.201800551