Hyperuricemia induces endothelial dysfunction
نویسندگان
چکیده
منابع مشابه
Carbamylated low-density lipoprotein induces endothelial dysfunction.
AIMS Cardiovascular events remain the leading cause of death in Western world. Atherosclerosis is the most common underlying complication driven by low-density lipoproteins (LDL) disturbing vascular integrity. Carbamylation of lysine residues, occurring primarily in the presence of chronic kidney disease (CKD), may affect functional properties of lipoproteins; however, its effect on endothelial...
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T he endothelium critically regulates the contractile status of the vascular smooth muscle cells. 1 Dysfunction of endothelial cells (ECs) induces the increased expression of adhesion molecules for inflammatory cells. 2 Inflammatory cell migration and vascular inflammation generate an oxidizing environment. The accumulating inflammatory cells produce abundant reactive oxygen species (ROS) and s...
متن کاملHyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women
OBJECTIVES The purpose of this study was to determine the relationships between uric acid, endothelial function and cardiovascular risk factors and to investigate whether menopausal status was associated with the relationship between uric acid and endothelial function in women. DESIGN Cross-sectional study. SETTING 3 general hospitals in Japan. PARTICIPANTS 749 Japanese women aged 30-74 y...
متن کاملPhloretin attenuates hyperuricemia‐induced endothelial dysfunction through co‐inhibiting inflammation and GLUT9‐mediated uric acid uptake
Hyperuricemia is an important risk factor for cardiovascular and renal diseases. Phloretin had shown antioxidant and anti-inflammatory properties, but its role in endothelial injury is rarely reported. In this study, we aimed to investigate the protective effect of phloretin on UA-induced injury in human umbilical vein endothelial cells. The effects of UA and phloretin on cell viability, inflam...
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In humans, hypercholesterolemia and hypertriglyceridemia induce endothelial dysfunction and therefore lead to atherosclerosis. In contrast, rats are resistant to atherosclerosis. Here we analyze whether rats respond to hypercholesterolemia and hypertriglyceridemia by developing of endothelial dysfunction. To induce hypercholesterolemiaWistar-Kyoto (WKY) and spontaneous hypertensive (SHR) rats w...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2005
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2005.00273.x