Hypoxia-induced changes in pulmonary and systemic vascular resistance: Where is the O2 sensor?
نویسندگان
چکیده
منابع مشابه
Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans.
OBJECTIVES This investigation sought to determine whether endothelium-derived nitric oxide contributes to hypoxia-induced systemic vasodilation and pulmonary vasoconstriction in humans. BACKGROUND Endothelium-derived nitric oxide contributes to basal systemic and pulmonary vascular resistance. During hypoxia, systemic vasodilation and pulmonary vasoconstriction occur. There are some data indi...
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• It is well known that hypoxia elicits an increase of pulmonary vascular resistance in man and in experimental animals.' Accumulated physiologic data suggest that hypoxia elicits vasoconstriction in either preor postcapillary vessels.' Anatomic studies have been inconclusive with reference to exact vasoconstrictor sites. It has been shown that chronic hypoxia leads to increased pulmonary arter...
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Pulmonary hypertension (PH) is a serious disease of multiple etiologies mediated by hypoxia, immune stimuli, and elevated pulmonary pressure that leads to vascular thickening and eventual right heart failure. In a chronic hypoxia model of PH, we previously reported the induction of a novel pleiotropic cytokine, hypoxia-induced mitogenic factor (HIMF), that exhibits mitogenic, vasculogenic, cont...
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Background: Some respiratory diseases may induce alveolar hypoxia thereby hypoxic pulmonary vasoconstriction (HPV). However, the mechanisms of this physiologic phenomenon are not fully understood. This study was the first to investigate the role of anion exchanger in sustained HPV.Methods: Experiments were performed in the isolated perfused rabbit lung. After preparation, the lungs were divided...
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1. Acute and chronic effects on the pulmonary circulation of ligustrazine, a chemically identified and synthesized principle of a Chinese herb, were studied in rats. It dilated lung vessels and reversed hypoxic pulmonary vasoconstriction. 2. In rats kept 2 weeks in 10% O2 in a normobaric chamber and simultaneously treated with ligustrazine, right ventricular hypertrophy and muscularization of p...
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ژورنال
عنوان ژورنال: Respiratory Physiology & Neurobiology
سال: 2010
ISSN: 1569-9048
DOI: 10.1016/j.resp.2010.08.007