Identification of a cis-acting element that localizes mRNA to synapses
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منابع مشابه
Characterization of a cis-acting element in the renal NaPi-2 co-transporter mRNA that determines mRNA stability
Hypophosphatemia leads to an increase in Na-Pi co-transporter (NaPi-2) mRNA levels. This increase is post-transcriptional and correlates with a more stable transcript mediated by the terminal 698 nt of the NaPi-2mRNA. A 71 nt binding element was identified using renal proteins from rats fed control and low Pi diet. The binding of (–) Pi renal proteins to this transcript was increased compared t...
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A previous study has shown that rotavirus cores have an associated replicase activity which can direct the synthesis of double-stranded RNA from viral mRNA in a cell-free system (D. Y. Chen, C. Q.-Y. Zeng, M. J. Wentz, M. Gorziglia, M. K. Estes, and R. F. Ramig, J. Virol. 68:7030-7039, 1994). To define the cis-acting signals in rotavirus mRNA that are important for RNA replication, gene 8 trans...
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We have previously demonstrated that two distinct transcripts are produced from ORF 50, the major transcriptional activating gene of herpesvirus saimiri. The products of these transcripts trans-activate the delayed-early ORF 6 promoter, though to different degrees. Deletion analysis demonstrated that the ORF 50 responsive elements are contained in a 132 bp fragment situated 127-259 bp from the ...
متن کاملCharacterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.
Thymidylate synthase (TS) functions as an RNA-binding protein by interacting with two different sequences on its own mRNA. One site is located in the 5'-upstream region of human TS mRNA while the second site is located within the protein coding region corresponding to nt 434-634. In this paper, a 70 nt RNA sequence, corresponding to nt 480-550, was identified that binds TS protein with an affin...
متن کاملCharacterization of the cis-acting element directing perinuclear localization of the metallothionein-1 mRNA.
Subcellular localization of mRNAs is a key mechanism for the synthesis of proteins close to their site of function. The mRNA encoding MT-1 (metallothionein-1) is localized in the perinuclear cytoplasm, where it is associated with cytoskeletal-bound polysomes. This localization relies on sequences present in the 3'-UTR (3'-untranslated region). The present study aims to characterize the cis-acti...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1116269109