Identification of autoreactive B cells with labeled nucleosomes
نویسندگان
چکیده
منابع مشابه
Redemption of autoreactive B cells.
Autoreactive antibodies can be pathogenic in a myriad of diseases. Consequently, the adaptive immune system actively removes or inactivates self-reactive B cells, while promoting the survival of B cells that recognize exogenous antigens, including microbial pathogens (1, 2). These physiological mechanisms of immune tolerance are often defective in autoimmune diseases (3, 4), and much effort is ...
متن کاملGenetics of autoreactive B cells.
It is now well-accepted that autoimmune diseases develop as a result of interactions between a complex genetic basis and environmental triggers. Autoreactive B cells play a major role in many autoimmune diseases, by secreting autoantibodies or cytokines and/or presenting auto-antigens to T cells. Studies performed with human patients and murine models have accumulated evidence that B-cell autor...
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Autoreact ive, immunocompe ten t B lymphocytes in peripheral lymphoid organs have long been considered "abnormal," as it was believed that such "forbidden clones" were normally deleted or inactivated in mature reper toi res (1-3). In fact, for the last 10 years autoreact ive B cells were shown to exist in available reper toi res by the appearance o f autoantibodies in graft vs. host disease and...
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Several powerful mechanisms exist to prevent self-reactive B cells from maturing to secrete potentially destructive autoantibodies. These mechanisms act in addition to the removal of self-reactive helper T cells.
متن کاملInduction of autoreactive B cells allows priming of autoreactive T cells
A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but als...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-00664-0