Identification of BRAF Inhibitors through In Silico Screening
نویسندگان
چکیده
منابع مشابه
in silico screening of IL-1β production inhibitors using chemometric tools
The IL-1β play a major role in inflammatory disorders and IL-1β production inhibitors can be used in the treatment of inflammatory and related diseases. In this study, quantitative relationships between the structures of 46 pyridazine derivatives (inhibitors of IL-1β production) and their activities were investigated by Multiple Linear Regression (MLR) technique Stepwise Regression Method (ES-S...
متن کاملin silico screening of IL-1β production inhibitors using chemometric tools
The IL-1β play a major role in inflammatory disorders and IL-1β production inhibitors can be used in the treatment of inflammatory and related diseases. In this study, quantitative relationships between the structures of 46 pyridazine derivatives (inhibitors of IL-1β production) and their activities were investigated by Multiple Linear Regression (MLR) technique Stepwise Regression Method (ES-S...
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Introduction The COP9 signalosome (CSN), a multi enzyme complex, is involved in cell cycle regulation. CSN possesses kinase activity that phosphorylates proteins such as p53 and c-Jun [1] and is therefore an interesting therapeutic target for anti-tumor drugs. There are known inhibitors (e.g. Curcurmin) of the kinase activity associated with the signalosome but they exhibit low binding constant...
متن کاملIdentification of potential P. falciparum transketolase inhibitors: pharmacophore design, in silico screening and docking studies
Transketolase, the most critical enzyme of the non-oxidative branch of the pentose phosphate pathway, has been reported as a novel target in Plasmodium falciparum as it has least homology with the human host. Homology model of P. falciparum transketolase (PfTk) was constructed using the crystal structure of S. cervisiae transketolase as a template, and used for the identification and prioritiza...
متن کاملDiscovery of Specific Inhibitors for Intestinal E. coli β-Glucuronidase through In Silico Virtual Screening
Glucuronidation is a major metabolism process of detoxification for carcinogens, 4-(methylnitrosamino)-1-(3-pyridy)-1-butanone (NNK) and 1,2-dimethylhydrazine (DMH), of reactive oxygen species (ROS). However, intestinal E. coli β-glucuronidase (eβG) has been considered pivotal to colorectal carcinogenesis. Specific inhibition of eβG may prevent reactivating the glucuronide-carcinogen and prot...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2008
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm800539g