Identification of Cl(Ca) channel distributions in olfactory cilia
نویسندگان
چکیده
منابع مشابه
Identification of Cl(Ca) channel distributions in olfactory cilia.
Identification of detailed features of neuronal systems is an important challenge in the biosciences today. Transduction of an odor into an electrical signal occurs in the membranes of the cilia. The Cl(Ca) channels that reside in the ciliary membrane are activated by calcium, allow a depolarizing efflux of Cl(-) and are thought to amplify the electrical signal to the brain.In this paper, a mat...
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The Ca(2+)-activated Cl(-) channel is considered a key constituent of odor transduction. Odorant binding to a specific receptor in the cilia of olfactory sensory neurons (OSNs) triggers a cAMP cascade that mediates the opening of a cationic cyclic nucleotide-gated channel (CNG), allowing Ca(2+) influx. Ca(2+) ions activate Cl(-) channels, generating a significant Cl(-) efflux, with a large cont...
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Olfactory epithelium from the frog was examined in the living state by light microscopy and in the fixed state by electron microscopy. Particular attention was paid to the layer of cilia and mucus which covers the surface of the epithelium. The olfactory cilia differed from typical cilia in that they (a) arose from bipolar neurons and had centrioles near their basal bodies, (b) were up to 200 m...
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Electro-olfactograms (EOGs) evoked by 8 odorants from frog olfactory epithelia during ciliary regrowth and during epithelial regeneration were analyzed. During ciliary regrowth following detergent-induced ciliary removal, EOG amplitudes initially increase proportionately with ciliary length. EOGs reach maximal amplitudes after 2 days of growth, when cilia are 40 micron long. Therefore olfactory...
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Individual olfactory receptor neurons vary widely in their responses to odorants. Olfactory stimulus reception occurs in the cilia of the receptor neurons. Thus, the variability among individual neurons could in part be due to differences among the olfactory cilia. We have quantified the known conductance properties of each of 117 frog olfactory cilia. From a strictly qualitative viewpoint, the...
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ژورنال
عنوان ژورنال: Mathematical Methods in the Applied Sciences
سال: 2008
ISSN: 0170-4214,1099-1476
DOI: 10.1002/mma.1007