Identification of crucial genes associated with lung adenocarcinoma by bioinformatic analysis

Gene Regulation Network Based Analysis Associated with TGF-beta Stimulation in Lung Adenocarcinoma Cells

Background: Transforming growth factor (TGF)-β is over-expressed in a wide variety of cancers such as lung adenocarcinoma. TGF-β plays a major role in cancer progression through regulating cancer cell proliferation and remodeling of the tumor micro-environment. However, it is still a great challenge to explain the phenotypic effects caused by TGF-β stimulation and the effect of TGF-β stimulatio...

Identification of key genes and crucial modules associated with coronary artery disease by bioinformatics analysis.

The aim of this study was to identify key genes associated with coronary artery disease (CAD) and to explore the related signaling pathways. Gene expression profiles of 110 CAD and 112 non-CAD, healthy patients [CAD index (CADi) >23 and =0, respectively] were downloaded from the Gene Expression Omnibus (GEO) database (accession: GSE12288). The differentially expressed genes (DEGs) in CAD were i...

Crucial genes associated with diabetic nephropathy explored by microarray analysis

BACKGROUND This study sought to investigate crucial genes correlated with diabetic nephropathy (DN), and their potential functions, which might contribute to a better understanding of DN pathogenesis. METHODS The microarray dataset GSE1009 was downloaded from Gene Expression Omnibus, including 3 diabetic glomeruli samples and 3 healthy glomeruli samples. The differentially expressed genes (DE...

Identification of crucial microRNAs and genes in hypoxia-induced human lung adenocarcinoma cells

BACKGROUND Variations of microRNA (miRNA) expression profile in hypoxic lung cancer cells have not been studied so far. Therefore, using miRNA microarray technology, this study aimed to study the miRNA expression profile and investigate the potential crucial miRNAs and their target genes in hypoxia-induced human lung adenocarcinoma cells. MATERIALS AND METHODS Based on miRNA microarray, miRNA...

Bioinformatic identification of disease associated pathways by network based analysis